Immunotherapy has become one of the most talked-about cancer treatments in Dubai over the last few years. Expert evaluation of your cancer type, stage, biomarkers, and treatment history can help determine whether immunotherapy may be an appropriate treatment option.
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Immunotherapy has become one of the most talked-about cancer treatments in Dubai over the last few years, and for good reason. It can produce durable results in cancers that used to be difficult to control, and it often comes with a different, sometimes gentler, side-effect profile than chemotherapy. But it is also one of the most misunderstood treatments, because it does not work for every cancer, and it does not work for every patient with the same cancer either. Eligibility is specific, testable, and needs to be confirmed before anyone commits to a treatment plan.
Dr. Ajeet Tiwari is an MCh surgical oncologist who reviews immunotherapy eligibility for patients in Dubai, walks through what the biomarker results actually mean in plain language, and puts together a treatment plan when immunotherapy is a genuine option, either on its own or alongside chemotherapy, surgery or targeted therapy.
This page explains how that eligibility decision is made, what it costs, and what the treatment itself looks like week to week.
Cancer cells are often able to hide from the immune system by producing proteins that switch off the immune cells sent to attack them. Immunotherapy drugs, most commonly a class called checkpoint inhibitors, block that switch-off signal, which allows the body's own immune system to recognise the cancer cells again and attack them directly. This is fundamentally different from chemotherapy, which works by killing rapidly dividing cells regardless of whether the immune system is involved at all.
The two most common checkpoint targets are PD-1, found on immune cells, and PD-L1, found on cancer cells. When a PD-1 inhibitor or PD-L1 inhibitor is given, it blocks this interaction, effectively removing the brake that was stopping the immune system from doing its job. The strength of this effect varies a great deal by cancer type and by how much PD-L1 the tumor is actually expressing, which is why testing comes before treatment, not after.
For a number of cancers, immunotherapy is not used as a stand-alone treatment but combined with chemotherapy, targeted therapy, or given after surgery to reduce the chance of recurrence. The combination that makes sense depends entirely on the cancer type, stage, and biomarker profile, and is one of the main things reviewed during your initial consultation.
There is no single test that says yes or no to immunotherapy across the board. Eligibility depends on a combination of factors specific to your tumor, and these are usually established from the same biopsy or surgical tissue sample already sitting in a pathology lab, which means eligibility can often be checked without any new procedure.
| Factor | What It Tells the Treating Team |
|---|---|
| PD-L1 expression | How much of the checkpoint protein the tumor is producing, which helps predict response to PD-1/PD-L1 inhibitors. |
| Microsatellite instability (MSI) status | Whether the tumor has a DNA repair defect that tends to respond well to immunotherapy across several cancer types. |
| Tumor mutation burden | How many genetic mutations the tumor carries; higher counts are sometimes linked to a stronger immunotherapy response. |
| Cancer type and stage | Some cancers respond well to immunotherapy as standard practice; others have limited or no established benefit. |
| Prior treatment history | What has already been tried and how the tumor responded, which shapes whether immunotherapy is used alone or combined. |
None of these factors are assessed in isolation. They are read together against your specific diagnosis, which is exactly why a proper second opinion, not a general assumption based on cancer type alone, is the right first step.
Patients in Dubai often ask whether immunotherapy simply replaces chemotherapy. It does not, and the two are not interchangeable, even though they are sometimes used together. The table below sets out the practical differences that tend to matter most when a patient is deciding between, or combining, the two.
| Aspect | Chemotherapy | Immunotherapy |
|---|---|---|
| How it works | Directly kills rapidly dividing cells, including cancer cells | Helps the immune system recognise and attack cancer cells |
| Typical side effects | Nausea, fatigue, hair loss, low blood counts | Fatigue, skin reactions, occasional inflammation in organs |
| Who it suits | Most solid tumors, often as a standard first step | Only cancers and patients matching specific biomarker criteria |
| Testing required first | General blood work and imaging | Biomarker testing such as PD-L1 or MSI status |
| Typical schedule | Cycles every 2–3 weeks over several months | Infusions every 2–4 weeks, often for a defined treatment period |
Immunotherapy drugs are among the more expensive cancer treatments anywhere in the world, and cost varies significantly depending on the specific drug, the number of infusions needed, and whether it is given alone or combined with chemotherapy. Rather than quoting a general figure that would not actually apply to your case, a written cost estimate is provided once your cancer type, stage, and biomarker results are known, so you have a specific number to work with rather than a wide range.
Treatment is given as an intravenous infusion, typically every two to four weeks depending on the specific drug and protocol used. Each infusion visit usually takes a few hours in a day-care setting and does not require an overnight hospital stay for most patients. Response is checked periodically through repeat imaging, generally every two to three months, to confirm the treatment is working before continuing the same plan or adjusting it.
Some immunotherapy protocols run for a fixed period, often around one to two years, while others continue as long as the treatment is working and side effects remain manageable. This is decided based on how your specific cancer responds and is reviewed at each scan, not fixed in advance.
Because immunotherapy works by activating the immune system rather than suppressing rapidly dividing cells, its side effects look different from chemotherapy and can, less commonly, affect organs such as the lungs, liver, thyroid or gut through an overactive immune response.
Most patients experience mild fatigue, occasional skin rash or itching, and sometimes joint discomfort, all of which are generally manageable with routine supportive care alongside treatment.
Less common but more serious reactions, such as persistent diarrhoea, shortness of breath, or unusual fatigue accompanied by other symptoms, need prompt attention rather than waiting for the next scheduled review. You are given clear written guidance on exactly what to watch for and who to contact if something feels off between visits.
This eligibility review and treatment planning process is not limited to patients based in Dubai. Cancer patients researching immunotherapy in Riyadh and Jeddah, Saudi Arabia, and in Kuwait use the same process described on this page: sending existing pathology and biomarker reports for review, a video consultation to discuss eligibility, and a written treatment and cost plan before any decision is made. Distance from Dubai does not change how the eligibility assessment works, only the specific travel arrangements involved.
If you already have a biopsy, surgical pathology, or biomarker report, send it through the online second opinion page. If biomarker testing has not yet been done, this is flagged during the initial review so it can be arranged before any decision on immunotherapy is finalised. From there, a video consultation covers whether immunotherapy applies to your case, what it would cost, and what an alternative plan would look like if it does not.
Find answers to common questions about immunotherapy, eligibility, biomarker testing, treatment costs, and international patient care.